In Path of Exile, the Orb of Chance remains a highly valued crafting currency due to its ability to upgrade a normal (white) base item into a random magic, rare, or unique item. Players who wish to maximize their chances of obtaining valuable unique items through chancing must choose the best base items carefully. Selecting the right base items can make the difference between striking gold and wasting valuable orbs.

One of the most sought-after bases for chancing is the Stellar Amulet. This base can yield the unique Astramentis, which is exceedingly rare and commands extremely high value. Although Astramentis has a slim chance of dropping, the payoff is huge, making the Stellar Amulet a popular and risky choice among players pursuing top-tier unique jewelry. The lack of attractive consolation uniques on this base means it's a pure gamble with a potentially epic reward.

Another prime base item is the Heavy Belt, which can be converted into the legendary unique Headhunter. Headhunter is famous for its powerful effects in the game, and although it has a low chance of appearing, the demand and value of this unique make heavy belts a high-risk, high-reward target for Orbs of Chance. Players willing to invest in multiple chancing attempts often turn to Heavy Belts to try their luck, especially when stocking up on poe 2 currency for sale through trading hubs.

Rings also offer notable unique outcomes when chanced. The Emerald Ring can become Thief's Torment or Death Rush, both valuable and sought-after uniques that have utility in many builds. Similarly, Gold Rings can yield Ventor's Gamble or Andvarius, although these are more variable in value due to the random modifiers they roll with, making them a more complicated risk to evaluate. The Octane provided by these rings, especially the chance for Ventor's Gamble, can create excitement despite the unpredictable outcome.

Ornate Belts are another solid choice because they can roll into Ryslatha’s Coil, which holds decent value and practical use. The Solar Amulet base offers the potential to become Fireflower, which gains value under certain conditions such as corruption. These bases tend to present less risk than Stellar Amulets or Heavy Belts but still retain the possibility of producing highly desirable uniques.

Several other bases are targeted for chancing depending on the player’s goals and the prevailing meta. Moulded Mitts can yield Atziri’s Acuity, an item with fluctuating value based on current play trends. Gold Amulets may drop specialized uniques like Eye of Chayula or Serpent’s Egg, though their worth varies with build popularity. Low item level Attuned Wands also feature notably for chancing Lifesprig, a valued leveling wand for certain builds.

An important aspect of using Orbs of Chance wisely is understanding that not all base types have associated unique items, and the chance to get the rarest uniques is slim, often requiring dozens to hundreds of orbs. Economic considerations also play a role, as players must weigh the value of the base item versus the potential unique outcome and the cost of the orbs used. For players on a budget, acquiring cheap poe 2 currency can make this gamble more manageable and keep the process sustainable.

The best base items to use the Orb of Chance on in Path of Exile are those with high-value, desirable unique versions and relatively attainable chances. Stellar Amulets and Heavy Belts head the list as top-tier gamble bases due to Astramentis and Headhunter. Rings and Ornate Belts offer a range of valuable and moderately valuable unique possibilities, blending risk and reward. Savvy chancers continually evaluate the market value and meta relevance to maximize their returns and enjoy the thrill of the gamble inherent in using the Orb of Chance.