1. Running Heist Missions
   Heists are highly rewarding for farming poe 2 currency because they frequently drop jewelry and flasks that can be either identified and sold or sold unidentified for Orbs. Running ultimatums during Heists enhances drops substantially, making it an excellent way to accumulate these orbs quickly.

2. Farming Maps with Nemesis or Harbinger Mods
   Maps that include Nemesis or Harbinger modifiers spawn additional rare monsters that drop extra currency items, including Orbs of Transmutation. Using Atlas passive tree enhancements and sextants to increase rare monster pack size further boosts the orb drop potential.

3. Picking Up and Selling Unidentified Magic Items
   Unidentified magic items such as rings, belts, and flasks, when sold to vendors, often yield Orbs of Transmutation. Picking these items instead of fully identifying them and selling them unidentified is a fast and inventory-efficient method to generate Orbs.

4. Disenchanting Magic Items into Transmutation Shards
   Disenchanting unwanted magic items gives Transmutation Shards, which can be combined into full Orbs of Transmutation. This method works well especially when players accumulate many magic items from farming or trading.

5. Farming Areas with High Monster Density
   Zones or maps with dense monster populations increase the sheer volume of drops, including Orbs of Transmutation. Delve and certain Expedition maps, for example, avoid portal limits and allow for continuous monster killing, efficiently generating poe 2 currency for sale through sustained combat.

6. Utilizing Loot Filters to Highlight Orbs
   Using loot filters that highlight Orbs of Transmutation and related currency makes it easier to spot and pick these up quickly during runs. This prevents missing orbs among large piles of items and speeds up farming time.

7. Selling Excess Rares and Flasks
   Selling excess rare items or utility flasks to vendors yields Orbs of Transmutation as currency. Prioritizing picking up jewelry, blue belts, and flasks, which vendor well, is a good practice to sustain orb supply without dedicating extra farming runs.

The most efficient farming combines active player strategies like running Heist ultimatums and high-density maps with passive methods like loot filtering and disenchanting. Such a combination maximizes orb acquisition speed, sustainability, and inventory space optimization, making the Orb of Transmutation readily available for all crafting needs.